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Version: 16.10e (Release date: 2016-10-31)
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Floxuridine (Code C504)

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Terms & Properties

Preferred Name: Floxuridine

Definition: A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)

NCI-GLOSS Definition: A drug used in the treatment of cancer. It is a type of antimetabolite.

Display Name: Floxuridine

Label: Floxuridine

NCI Thesaurus Code: C504 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0947603  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
2'-Deoxy-5-fluorouridine
2-Deoxy-5-fluorouridine
5-Fluoro-2'-deoxy-beta-uridine
5-Fluoro-2'-deoxyuridine
5-Fluorodeoxyuridine
5-Fluorouracil Deoxyriboside
5-Fluorouracil deoxyriboside
5-Fluorouridine Deoxyribose
5-FUDR
5-FUdR
FDUR
Floxuridin
Floxuridine
FLOXURIDINE
floxuridine
Fluorodeoxyuridine
Fluorouridine Deoxyribose
Fluoruridine Deoxyribose
Fluoruridine deoxyribose
FUDR
FUdR
WR-138720

External Source Codes: 
CAS Registry Number 50-91-9 (see NLM ChemIDplus info)
FDA UNII Code 039LU44I5M
ChEBI ID CHEBI:60761 (see ChEBI info)
NSC Code 27640 (see NCI DTP info)
PDQ Closed Trial Search ID 39242
PDQ Open Trial Search ID 39242 (check for NCI PDQ open clinical trial info)
UMLS CUI C0947603

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Gastrointestinal adenocarcinoma metastatic to the liver
Chemical_Formula C9H11FN2O5
code C504
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Floxuridine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C504

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