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Version: 17.06d (Release date: 2017-06-26)
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Flucytosine (Code C501)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Flucytosine

Definition: A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis.

NCI-GLOSS Definition: A drug that treats infections caused by fungi.

Display Name: Flucytosine

Label: Flucytosine

NCI Thesaurus Code: C501 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016278  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Amino-5-fluoro-2(1H)-pyrimidinone
5-FC
5-Fluorocytosine
Alcobon
Ancobon
Ancotil
Flucytosine
FLUCYTOSINE
flucytosine
Ro-2-9915
Ro 2-9915

External Source Codes: 
CAS Registry Number 2022-85-7 (see NLM ChemIDplus info)
FDA UNII Code D83282DT06
ChEBI ID CHEBI:5100 (see ChEBI info)
NSC Code 103805 (see NCI DTP info)
PDQ Closed Trial Search ID 41023
PDQ Open Trial Search ID 41023 (check for NCI PDQ open clinical trial info)
UMLS CUI C0016278

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C4H4FN3O
code C501
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Flucytosine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C501

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