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Version: 17.06d (Release date: 2017-06-26)
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Fluconazole (Code C500)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluconazole

Definition: A synthetic triazole with antifungal activity. Fluconazole preferentially inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols, the loss of normal fungal sterols, and fungistatic activity. Mammalian cell demethylation is much less sensitive to fluconazole inhibition.

NCI-GLOSS Definition: A drug that treats infections caused by fungi.

Display Name: Fluconazole

Label: Fluconazole

NCI Thesaurus Code: C500 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0016277  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol
Diflucan
Fluconazole
FLUCONAZOLE
fluconazole

External Source Codes: 
CAS Registry Number 86386-73-4 (see NLM ChemIDplus info)
FDA UNII Code 8VZV102JFY
ChEBI ID CHEBI:46081 (see ChEBI info)
PDQ Closed Trial Search ID 40842
PDQ Open Trial Search ID 40842 (check for NCI PDQ open clinical trial info)
UMLS CUI C0016277

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Antifungal, prophylaxis in allogeneic bone marrow transplantation; Candidiasis; Cryptococcal meningitis
Chemical_Formula C13H12F2N6O
code C500
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fluconazole
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C500

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