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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Interferon Beta (Code C495)

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Terms & Properties

Preferred Name: Recombinant Interferon Beta

Definition: A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI05)

Display Name: Recombinant Interferon Beta

Label: Recombinant Interferon Beta

NCI Thesaurus Code: C495 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0015980  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Betantrone
Beta Interferon
Feron
Human Interferon Beta
Interferon, Beta
Interferon-B
Interferon-beta
Interferon Beta
Naferon
Recombinant Interferon Beta

External Source Codes: 
CAS Registry Number 77238-31-4 (see NLM ChemIDplus info)
NSC Code 373361 (see NCI DTP info)
NSC Code 658933 (see NCI DTP info)
PDQ Closed Trial Search ID 40468
PDQ Open Trial Search ID 40468 (check for NCI PDQ open clinical trial info)
UMLS CUI C0015980

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For multiple sclerosis
code C495
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interferon_Beta
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C495

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