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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Adenovirus-L523S Vaccine (Code C49289)

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Terms & Properties

Preferred Name: Recombinant Adenovirus-L523S Vaccine

Definition: A replication-defective adenovirus containing a gene that encodes the human protein L523S with potential antineoplastic activity. Upon administration, recombinant adenovirus-L523S vaccine expresses L523S, which may stimulate antibody and cytotoxic T lymphocyte (CTL) responses against tumor cells expressing L523S. L523S is an RNA-binding protein that belongs to the KOC (K homology domain containing protein over-expressed in cancer) family of proteins. As an oncofetal protein, L523S is normally expressed in early embryonic tissues and certain normal adult tissues such as colon, fallopian tube, gall bladder, and ovary tissues but may be overexpressed in squamous cell cancers of the lung.

Label: Recombinant Adenovirus-L523S Vaccine

NCI Thesaurus Code: C49289 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328161  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad/L523S
Recombinant Adenovirus-L523S Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 353187
PDQ Open Trial Search ID 353187 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328161

Other Properties:
     Name Value (qualifiers indented underneath)
code C49289
Legacy_Concept_Name Recombinant_Adenovirus-L523S_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49289

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