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Version: 17.06d (Release date: 2017-06-26)
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AEG35156 (Code C49180)

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Terms & Properties

Preferred Name: AEG35156

Definition: A second-generation synthetic antisense oligonucleotide with potential antineoplastic activity. AEG35156 selectively blocks the cellular expression of X-linked inhibitor of apoptosis protein (XIAP), a pivotal inhibitor of apoptosis that is overexpressed in many tumors. This agent reduces total levels of XIAP in tumor cells, working synergistically with cytotoxic drugs to overcome tumor cell resistance to apoptosis. XIAP interferes with both the intrinsic and extrinsic program-death signaling pathways, which may render tumor cells resistant to apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. AEG35156 may kill cancer cells by blocking the production of a protein called XIAP that helps cells live longer. It also makes cancer cells more sensitive to anticancer drugs. It is a type of antisense oligonucleotide, and a type of chemosensitizing agent.

Display Name: AEG35156

Label: AEG35156

NCI Thesaurus Code: C49180 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1567121  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AEG35156
GEM640

External Source Codes: 
PDQ Closed Trial Search ID 492218
PDQ Open Trial Search ID 492218 (check for NCI PDQ open clinical trial info)
UMLS CUI C1567121

Other Properties:
     Name Value (qualifiers indented underneath)
code C49180
Contributing_Source CTRP
Legacy_Concept_Name AEG35156
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49180

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