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Version: 17.06d (Release date: 2017-06-26)
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PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1 (Code C49178)

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Terms & Properties

Preferred Name: PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1

Definition: A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) encapsulated in a biodegradable, biocompatible lipoplex composed of polyethylene glycol (PEG), polyethylenimine (PEI), and cholesterol, with potential immunoactivating and antineoplastic activities. Upon intraperitoneal (IP) delivery of the PEG-PEI-cholesterol lipopolymer-encased IL-12 DNA plasmid vector GEN-1, the lipoplex is endocytosed by nearby cells, and the plasmid DNA is transported into the nucleus, which leads to local expresssion of IL-12. In turn, the increased IL-12 production at the tumor site activates the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma (IFN-g) and promoting cytotoxic T-cell responses against tumor cells.

Display Name: PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1

Label: PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1

NCI Thesaurus Code: C49178 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1707844  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GEN-1
IL-12 Plasmid Formulated With PEG-PEI-Cholesterol Lipopolymer
Nanoparticle-encased IL-12 DNA Plasmid Vector
PEG-PEI-cholesterol Lipopolymer-encased IL-12 DNA Plasmid Vector GEN-1
phIL-12-005

External Source Codes: 
PDQ Closed Trial Search ID 454593
PDQ Open Trial Search ID 454593 (check for NCI PDQ open clinical trial info)
UMLS CUI C1707844

Other Properties:
     Name Value (qualifiers indented underneath)
code C49178
Contributing_Source CTRP
Legacy_Concept_Name EGEN-001
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49178

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