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Version: 17.06d (Release date: 2017-06-26)
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Palbociclib (Code C49176)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Palbociclib

Definition: An orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-dependent kinase 4 (CDK4) and 6 (CDK6), thereby inhibiting retinoblastoma (Rb) protein phosphorylation early in the G1 phase leading to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of cell cycle progression.

Display Name: Palbociclib

Label: Palbociclib

NCI Thesaurus Code: C49176 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3853822  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-8h-pyrido(2,3-d)pyrimidin-7-one
Ibrance
Palbociclib
PALBOCICLIB
PD-0332991
PD-332991

External Source Codes: 
CAS Registry Number 571190-30-2 (see NLM ChemIDplus info)
FDA UNII Code G9ZF61LE7G
PDQ Closed Trial Search ID 454586
PDQ Open Trial Search ID 454586 (check for NCI PDQ open clinical trial info)
UMLS CUI C3853822

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H29N7O2
code C49176
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PD-0332991
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49176

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