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Version: 17.06d (Release date: 2017-06-26)
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Notch Signaling Pathway Inhibitor MK0752 (Code C49175)

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Terms & Properties

Preferred Name: Notch Signaling Pathway Inhibitor MK0752

Definition: A synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks signals between growing cells and may kill cancer cells. It is a type of signal transduction inhibitor.

Display Name: Notch Signaling Pathway Inhibitor MK0752

Label: Notch Signaling Pathway Inhibitor MK0752

NCI Thesaurus Code: C49175 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1708824  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MK0752
Notch Signaling Pathway Inhibitor MK0752

External Source Codes: 
PDQ Closed Trial Search ID 446541
PDQ Open Trial Search ID 446541 (check for NCI PDQ open clinical trial info)
UMLS CUI C1708824

Other Properties:
     Name Value (qualifiers indented underneath)
code C49175
Contributing_Source CTRP
Legacy_Concept_Name MK0752
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49175

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