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Version: 17.06d (Release date: 2017-06-26)
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Aprepitant (Code C49173)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Aprepitant

Definition: A small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.

NCI-GLOSS Definition: A drug used together with other drugs to prevent and control the nausea and vomiting caused by cancer treatment. It is also used to treat nausea and vomiting after surgery. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist.

Display Name: Aprepitant

Label: Aprepitant

NCI Thesaurus Code: C49173 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1176306  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-1,2-dihydro-3H-1,2,4-Triazol-3-one
Aprepitant
APREPITANT
aprepitant
Emend
L-754030
MK-0869
ONO-7436

External Source Codes: 
CAS Registry Number 170729-80-3 (see NLM ChemIDplus info)
FDA UNII Code 1NF15YR6UY
ChEBI ID CHEBI:499361 (see ChEBI info)
PDQ Closed Trial Search ID 454517
PDQ Open Trial Search ID 454517 (check for NCI PDQ open clinical trial info)
UMLS CUI C1176306

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H21F7N4O3
code C49173
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Aprepitant
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49173

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