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Version: 17.06d (Release date: 2017-06-26)
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11C Topotecan (Code C49172)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: 11C Topotecan

Definition: A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata radiolabeled with carbon 11 (11C) with antineoplastic and radiotracer properties. During the S phase of the cell cycle, topotecan inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Quantitation of 11C topotecan accumulated in tumor tissues by positron emission tomography (PET) may help predict responses to topotecan therapy.

NCI-GLOSS Definition: A substance being studied in the treatment of certain types of cancer, including ovarian cancer and lung cancer. 11C topotecan is a radioactive form of the anticancer drug topotecan. It builds up in tumor tissues and is detected by positron emission tomography (PET). It may be used to help determine whether treatment with topotecan will work. It is a type of topoisomerase I inhibitor.

Label: 11C Topotecan

NCI Thesaurus Code: C49172 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1711433  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
11C topotecan
11C Topotecan

External Source Codes: 
PDQ Closed Trial Search ID 454314
PDQ Open Trial Search ID 454314 (check for NCI PDQ open clinical trial info)
UMLS CUI C1711433

Other Properties:
     Name Value (qualifiers indented underneath)
code C49172
Legacy_Concept_Name _11C_Topotecan
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49172

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