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Version: 17.12d (Release date: 2017-12-26)
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Etoposide (Code C491)

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Terms & Properties

Preferred Name: Etoposide

Definition: A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04)

NCI-GLOSS Definition: A drug used to treat testicular and small cell lung cancers. It is also being studied in the treatment of several other types of cancer. Vepesid blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.

Display Name: Etoposide

Label: Etoposide

NCI Thesaurus Code: C491 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0015133  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside]
Demethyl Epipodophyllotoxin Ethylidine Glucoside
VP 16-213

External Source Codes: 
CAS Registry Number 33419-42-0 (see NLM ChemIDplus info)
ChEBI ID CHEBI:4911 (see ChEBI info)
NSC Code 141540 (see NCI DTP info)
PDQ Closed Trial Search ID 39207
PDQ Open Trial Search ID 39207 (check for NCI PDQ open clinical trial info)
UMLS CUI C0015133

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute leukemia; Adrenal cortical cancer; Brain cancer; Chronic Lymphocytic leukemia; Choriocarcinoma; Esophageal cancer; Ewing's sarcoma; Gastric cancer; Germ Cell cancer; Gestational trophoblastic neoplasms; Hepatocellular cancer; Hodgkin's disease
Accepted_Therapeutic_Use_For Hypereosinophilic syndrome; Kaposi's sarcoma; Langerhans cell histiocytosis; Mobilization of peripheral-blood progenitor cells; Multiple myeloma; Neuroblastoma; Non-small lung cancer; Osteogenic sarcoma
Accepted_Therapeutic_Use_For Ovarian cancer; Retinoblastoma; Small cell lung cancer; Soft tissue sarcomas; Testicular cancer; Thymoma; Thyroid cancer; Uterine cancer; Wilms' tumor
Chemical_Formula C29H32O13
code C491
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Etoposide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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