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Version: 17.06d (Release date: 2017-06-26)
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Alvimopan (Code C49096)

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Terms & Properties

Preferred Name: Alvimopan

Definition: A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.

Display Name: Alvimopan

Label: Alvimopan

NCI Thesaurus Code: C49096 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1508750  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADL8-2698
Alvimopan
ALVIMOPAN
Entereg
LY-246376

External Source Codes: 
CAS Registry Number 170098-38-1 (see NLM ChemIDplus info)
FDA UNII Code 677C126AET
PDQ Closed Trial Search ID 453551
PDQ Open Trial Search ID 453551 (check for NCI PDQ open clinical trial info)
UMLS CUI C1508750

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H32N2O4.2H2O
code C49096
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Alvimopan
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49096

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