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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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CC-401 (Code C49095)

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Terms & Properties

Preferred Name: CC-401

Definition: A second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation.

Label: CC-401

NCI Thesaurus Code: C49095 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1707079  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 453550
PDQ Open Trial Search ID 453550 (check for NCI PDQ open clinical trial info)
UMLS CUI C1707079

Other Properties:
     Name Value (qualifiers indented underneath)
code C49095
Legacy_Concept_Name CC-401
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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