skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
Neratinib (Code C49094)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Neratinib

Definition: An orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.

Display Name: Neratinib

Label: Neratinib

NCI Thesaurus Code: C49094 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1704439  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HKI-272
Neratinib
NERATINIB

External Source Codes: 
CAS Registry Number 698387-09-6 (see NLM ChemIDplus info)
FDA UNII Code JJH94R3PWB
ChEBI ID CHEBI:61397 (see ChEBI info)
PDQ Closed Trial Search ID 453548
PDQ Open Trial Search ID 453548 (check for NCI PDQ open clinical trial info)
UMLS CUI C1704439

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C30H29ClN6O3
code C49094
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name KI-272
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49094

Mainbox Bottom