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Version: 17.06d (Release date: 2017-06-26)
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Fluorothymidine F-18 (Code C49093)

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Terms & Properties

Preferred Name: Fluorothymidine F-18

Definition: A radioconjugate consisting of a thymidine analogue radiolabeled with fluorine F 18, a positron emitting isotope. Phosphorylated by S-phase-specific thymidine kinase 1, 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) is trapped intracellularly by entering the salvage pathway of DNA synthesis without incorporation into DNA. 18F-FLT serves a marker of tumor cell proliferation for imaging with positron emission tomography (PET); as a marker of proliferation rather than metabolism, it is more specific to tumor tissue than 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG). This agent is metabolically stable, accumulates in the normal bone marrow and the liver, and does not cross the blood-brain barrier.

NCI-GLOSS Definition: A radioactive substance being studied in the diagnosis of cancer. 18F-FLT is injected into the blood and builds up in cells that are dividing, including cancer cells. The radiation that it gives off as it decays (breaks down) helps make clear pictures of tumors during positron emission tomography (PET) scans. It is a type of radiopharmaceutical.

Display Name: Fluorothymidine F-18

Label: Fluorothymidine F-18

NCI Thesaurus Code: C49093 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1432709  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-FLT
3'-deoxy-3'-(18F) fluorothymidine
3'-Deoxy-3'-(18F) Fluorothymidine
3'-deoxy-3'-[18F]fluorothymidine
Fluorothymidine F-18
FLUOROTHYMIDINE F-18
fluorothymidine F 18
Fluorothymidine F 18
Thymidine, 3'-deoxy-3'-(18F)fluoro-

External Source Codes: 
CAS Registry Number 287114-80-1 (see NLM ChemIDplus info)
FDA UNII Code 2X1K91UT6N
PDQ Closed Trial Search ID 453547
PDQ Open Trial Search ID 453547 (check for NCI PDQ open clinical trial info)
UMLS CUI C1432709

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H13FN2O4
code C49093
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _18F-FLT
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49093

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