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Version: 17.08d (Release date: 2017-08-28)
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Immunomodulator OHR/AVR118 (Code C49092)

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Terms & Properties

Preferred Name: Immunomodulator OHR/AVR118

Definition: A broad-spectrum peptide nucleic acid formulation comprised of breakdown products of casein, peptone, RNA and serum albumin, with potential anti-inflammatory, immunomodulatory, anti-anorectic and anti-cachexia activities. AVR118 mainly contains two peptides, peptide A and peptide B, in approximately a 1:1 ratio: peptide A (31 a. a.) is derived from bovine casein; peptide B (21 a. a.) is covalently linked via phosphodiester bond to a diadenosine unit. In addition, AVR118 contains nucleosides, nucleoside diphosphates and nucleoside monophosphates. Upon subcutaneous injection of AVR118, this agent affects the synthesis of many pro-inflammatory chemokines and cytokines, especially monocyte chemotactic protein-1 (MCP-1), interleukin (IL)-8, IL-1 beta, IL-6, and tumor necrosis factor-alpha (TNF-alpha). In particular, AVR118 stimulates macrophages to produce these mediators while in highly activated macrophages this agent inhibits their synthesis. This way, AVR118 may prevent the excessive release of cytokines seen during chemotherapy. Controlling the release of pro-inflammatory mediators may ultimately improve appetite and mood, increase strength and weight gain, and decrease fatigue.

Label: Immunomodulator OHR/AVR118

NCI Thesaurus Code: C49092 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1172837  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AVR118
Immunomodulator OHR/AVR118
Product R

External Source Codes: 
PDQ Closed Trial Search ID 686449
PDQ Closed Trial Search ID 453546
PDQ Open Trial Search ID 686449 (check for NCI PDQ open clinical trial info)
PDQ Open Trial Search ID 453546 (check for NCI PDQ open clinical trial info)
UMLS CUI C1172837

Other Properties:
     Name Value (qualifiers indented underneath)
code C49092
Legacy_Concept_Name AVR118
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49092

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