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National Cancer Institute
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Version: 16.11d (Release date: 2016-11-28)
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BI 2536 (Code C49091)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: BI 2536

Definition: A small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It prevents cells from dividing and may block the growth of some tumors. It is a type of mitotic inhibitor.

Display Name: BI 2536

Label: BI 2536

NCI Thesaurus Code: C49091 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1706888  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BI 2536

External Source Codes: 
PDQ Closed Trial Search ID 452943
PDQ Open Trial Search ID 452943 (check for NCI PDQ open clinical trial info)
UMLS CUI C1706888

Other Properties:
Name Value (qualifiers indented underneath)
code C49091
Contributing_Source CTRP
Legacy_Concept_Name BI_2536
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49091

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