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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Modified Vaccinia Ankara-5T4 Vaccine (Code C49087)

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Terms & Properties

Preferred Name: Recombinant Modified Vaccinia Ankara-5T4 Vaccine

Definition: A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the 5T4 fetal oncoprotein (MVA-h5T4). Vaccination with recombinant modified vaccinia Ankara-5T4 vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing 5T4 fetal oncoprotein antigen, resulting in tumor cell lysis. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attenuated, replication-defective vaccinia strain incapable of virion assembly.

Display Name: Recombinant Modified Vaccinia Ankara-5T4 Vaccine

Label: Recombinant Modified Vaccinia Ankara-5T4 Vaccine

NCI Thesaurus Code: C49087 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541801  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Modified Vaccinia Ankara-5T4 Vaccine
Recombinant MVA-5T4 Vaccine
Recombinant Pox Virus Encoding 5T4 Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 449683
PDQ Open Trial Search ID 449683 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541801

Other Properties:
     Name Value (qualifiers indented underneath)
code C49087
Contributing_Source CTRP
Legacy_Concept_Name Recombinant_Modified_Vaccinia_Ankara-5T4_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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