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Version: 17.06d (Release date: 2017-06-26)
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Imetelstat (Code C49084)

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Terms & Properties

Preferred Name: Imetelstat

Definition: A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase (hTR) RNA, imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis.

Label: Imetelstat

NCI Thesaurus Code: C49084 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2746063  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate]

External Source Codes: 
CAS Registry Number 868169-64-6 (see NLM ChemIDplus info)
UMLS CUI C2746063

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C148H211N68O53P13S13
code C49084
Contributing_Source FDA
Legacy_Concept_Name GRN163L
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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