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Version: 17.12d (Release date: 2017-12-26)
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Hemiasterlin Analog E7974 (Code C49083)

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Terms & Properties

Preferred Name: Hemiasterlin Analog E7974

Definition: An analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of existing microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype.

Label: Hemiasterlin Analog E7974

NCI Thesaurus Code: C49083 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1708344  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hemiasterlin Analog E7974

External Source Codes: 
PDQ Closed Trial Search ID 447049
PDQ Open Trial Search ID 447049 (check for NCI PDQ open clinical trial info)
UMLS CUI C1708344

Other Properties:
     Name Value (qualifiers indented underneath)
code C49083
Legacy_Concept_Name Hemiasterlin_Analog_7974
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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