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Version: 17.06d (Release date: 2017-06-26)
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Retrovector Encoding Mutant Anti-Cyclin G1 (Code C49082)

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Terms & Properties

Preferred Name: Retrovector Encoding Mutant Anti-Cyclin G1

Definition: A replication-incompetent, pathotropic, tumor matrix (collagen)-targeted, retroviral vector encoding an N-terminal deletion mutant form of the cyclin G1 gene with potential antineoplastic activity. Under the control of a hybrid long-terminal repeat/cytomegalovirus (CMV) promoter, retrovector encoding mutant anti-cyclin G expresses the mutant cyclin G1 construct, resulting in disruption of tumor cell cyclin G1 activity and decreased cellular proliferation and angiogenesis. This agent preferentially targets collagen of the tumor matrix because of the incorporation of the collagen-binding domain of von Willebrand factor (vWF) on the retrovector surface. Exploiting the collagen-targeting mechanism of vWF permits delivery of the retrovector to tumor sites where angiogenesis and collagen matrix exposure occur.

Display Name: Retrovector Encoding Mutant Anti-Cyclin G1

Label: Retrovector Encoding Mutant Anti-Cyclin G1

NCI Thesaurus Code: C49082 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1709935  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Mx-dnG1
Retrovector Encoding Mutant Anti-Cyclin G1
REXIN-G

External Source Codes: 
PDQ Closed Trial Search ID 446577
PDQ Open Trial Search ID 446577 (check for NCI PDQ open clinical trial info)
UMLS CUI C1709935

Other Properties:
     Name Value (qualifiers indented underneath)
code C49082
Contributing_Source CTRP
Legacy_Concept_Name Retrovector_Encoding_Anti-Cyclin_G
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C49082

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