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Version: 16.10e (Release date: 2016-10-31)
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Belinostat (Code C48812)

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Terms & Properties

Preferred Name: Belinostat

Definition: A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. Belinostat blocks enzymes needed for cell division and may kill cancer cells. It also prevents the growth of blood vessels needed for tumors to grow and may make tumor cells more sensitive to other anticancer drugs. It is a type of histone deacetylase (HDAC) inhibitor, a type of angiogenesis inhibitor, and a type of chemosensitizer.

Display Name: Belinostat

Label: Belinostat

NCI Thesaurus Code: C48812 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1948068  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Beleodaq
Belinostat
BELINOSTAT
belinostat
PXD101
PXD 101

External Source Codes: 
CAS Registry Number 414864-00-9 (see NLM ChemIDplus info)
FDA UNII Code F4H96P17NZ
ChEBI ID CHEBI:61076 (see ChEBI info)
NSC Code 726630 (see NCI DTP info)
PDQ Closed Trial Search ID 454583
PDQ Open Trial Search ID 454583 (check for NCI PDQ open clinical trial info)
UMLS CUI C1948068

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C15H14N2O4S
code C48812
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PXD101
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48812

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