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Version: 17.06d (Release date: 2017-06-26)
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Amifostine (Code C488)

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Terms & Properties

Preferred Name: Amifostine

Definition: The trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.

Display Name: Amifostine

Label: Amifostine

NCI Thesaurus Code: C488 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0015020  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester Trihydrate
Amifostine
AMIFOSTINE
Amifostine Trihydrate
Aminopropylaminoethylthiophosphoric Acid Trihydrate
APAETP
Cytofos
Ethiofos
Ethyol
Gammaphos
S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid Trihydrate
S-2-(3-Aminopropylamino)ethylphosphorothioic Acid Trihydrate
WR-2721
WR2721
WR 2721
YM-08310

External Source Codes: 
CAS Registry Number 112901-68-5 (see NLM ChemIDplus info)
FDA UNII Code M487QF2F4V
NSC Code 296961 (see NCI DTP info)
PDQ Closed Trial Search ID 39741
PDQ Open Trial Search ID 39741 (check for NCI PDQ open clinical trial info)
UMLS CUI C0015020

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cisplatin-induced nephrotoxicity; Radiation-induced mucositis and xerostomia
Chemical_Formula C5H15N2O3PS.3H2O
code C488
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Amifostine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C488

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