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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Vaccinia-Multiepitope Melanoma Peptides-B7.1-B7.2 Vaccine (Code C48638)

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Terms & Properties

Preferred Name: Recombinant Vaccinia-Multiepitope Melanoma Peptides-B7.1-B7.2 Vaccine

Definition: A cancer vaccine consisting of an inactivated recombinant vaccinia virus encoding epitope peptides derived from melanoma-related HLA-A2-restricted tumor-associated antigens (TAAs), including Melan-A(27-35), gp100(280-288) and tyrosinase(1-9), and two co-stimulatory B7 proteins, B7.1 (CD80) and B7.2 (CD86). Upon administration, recombinant vaccinia-multiepitope melanoma peptides-B7.1-B7.2 vaccine may stimulate a cytotoxic T-lymphocyte response against melanoma cells that express TAAs which share epitopes with the epitope peptides expressed by the vaccine viral vector, resulting in tumor cell lysis; vaccine viral vector-expressed co-stimulatory proteins B7.1 and B7.2 may enhance the cytotoxic T-lymphocyte immune response to the TAAs.

Label: Recombinant Vaccinia-Multiepitope Melanoma Peptides-B7.1-B7.2 Vaccine

NCI Thesaurus Code: C48638 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1709860  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Vaccinia-Multiepitope Melanoma Peptides-B7.1-B7.2 Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 445463
PDQ Open Trial Search ID 445463 (check for NCI PDQ open clinical trial info)
UMLS CUI C1709860

Other Properties:
     Name Value (qualifiers indented underneath)
code C48638
Legacy_Concept_Name Recombinant_Vaccinia-Multiepitope_Melanoma_Peptides-B7_1-B7_2_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48638

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