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Version: 17.06d (Release date: 2017-06-26)
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Ethinyl Estradiol (Code C486)

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Terms & Properties

Preferred Name: Ethinyl Estradiol

Definition: A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04)

Display Name: Ethinyl Estradiol

Label: Ethinyl Estradiol

NCI Thesaurus Code: C486 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0015011  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Diogyn E
Ethinyl Estradiol

External Source Codes: 
CAS Registry Number 57-63-6 (see NLM ChemIDplus info)
FDA UNII Code 423D2T571U
ChEBI ID CHEBI:4903 (see ChEBI info)
NSC Code 10973 (see NCI DTP info)
PDQ Closed Trial Search ID 39238
PDQ Open Trial Search ID 39238 (check for NCI PDQ open clinical trial info)
UMLS CUI C0015011

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis
Chemical_Formula C20H24O2
code C486
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ethinyl_Estradiol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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