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Version: 17.06d (Release date: 2017-06-26)
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Zibotentan (Code C48430)

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Terms & Properties

Preferred Name: Zibotentan

Definition: An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. Zibotentan binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation.

NCI-GLOSS Definition: A substance that is being studied in the treatment of prostate cancer. It belongs to the family of drugs called endothelin-receptor antagonists.

Display Name: Zibotentan

Label: Zibotentan

NCI Thesaurus Code: C48430 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328193  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-
N-(3-methoxy-5-methylpyrazin-2-yl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]pridine-3- sulfonamide

External Source Codes: 
CAS Registry Number 186497-07-4 (see NLM ChemIDplus info)
FDA UNII Code 8054MM4902
PDQ Closed Trial Search ID 355727
PDQ Open Trial Search ID 355727 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328193

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H16N6O4S
code C48430
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name ZD4054
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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