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Version: 16.11d (Release date: 2016-11-28)
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Yttrium Y-90 Clivatuzumab Tetraxetan (Code C48429)

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Terms & Properties

Preferred Name: Yttrium Y-90 Clivatuzumab Tetraxetan

Definition: A radioimmunoconjugate comprised of the humanized monoclonal antibody clivatuzumab, directed against the pancreatic cancer antigen MUC1, that is conjugated to the chelating agent tetraxetan and radiolabeled with the beta-emitting radioisotope Yttrium Y 90. Yttrium Y 90 clivatuzumab tetraxetan binds to tumor cells expressing MUC1 antigen, thereby selectively delivering a cytotoxic dose of beta radiation.

NCI-GLOSS Definition: A substance being studied in the treatment of advanced pancreatic cancer. HuPAM4 is a monoclonal antibody that can locate and bind to pancreatic cancer cells. It is linked to a radioactive substance called yttrium Y90, which may help kill cancer cells. Yttrium Y 90 DOTA monoclonal antibody HuPAM4 is a type of radioimmunoconjugate.

Display Name: Yttrium Y-90 Clivatuzumab Tetraxetan

Label: Yttrium Y-90 Clivatuzumab Tetraxetan

NCI Thesaurus Code: C48429 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541526  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
90Y-hPAM4
hPAM4-Cide
hPAM4-DOTA
IMMU-107
Yttrium Y-90 Clivatuzumab Tetraxetan
YTTRIUM Y-90 CLIVATUZUMAB TETRAXETAN
Yttrium Y 90 Clivatuzumab Tetraxetan
Yttrium Y 90 DOTA Monoclonal Antibody HuPAM4
yttrium Y 90 DOTA monoclonal antibody HuPAM4

External Source Codes: 
CAS Registry Number 943976-23-6 (see NLM ChemIDplus info)
FDA UNII Code 2L271110ED
PDQ Closed Trial Search ID 425350
PDQ Open Trial Search ID 425350 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541526

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C16H25N5O7.Y
code C48429
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Yttrium_Y_90_DOTA_Monoclonal_Antibody_HuPAM4
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48429

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