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Version: 17.12d (Release date: 2017-12-26)
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Yttrium Y-90 Tacatuzumab Tetraxetan (Code C48428)

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Terms & Properties

Preferred Name: Yttrium Y-90 Tacatuzumab Tetraxetan

Definition: A radioimmunoconjugate comprised of the humanized monoclonal antibody tacatuzumab, directed against alpha fetoprotein, that is conjugated to the chelating agent tetraxetan and radiolabeled with the beta-emitting radioisotope Yttrium Y 90. Yttrium Y 90 tacatuzumab tetraxetan binds to tumor cells expressing alpha fetoprotein, thereby selectively delivering a cytotoxic dose of beta radiation.

NCI-GLOSS Definition: A substance being studied in the treatment of liver cancer. HuAFP31 is a monoclonal antibody that can bind to tumor cells that make a protein called alpha fetoprotein (AFP). It is linked to a radioactive substance called yttrium Y 90, which may help kill the cancer cells. Yttrium Y 90 DOTA monoclonal antibody HuAFP31 is a type of radioimmunoconjugate.

Label: Yttrium Y-90 Tacatuzumab Tetraxetan

NCI Thesaurus Code: C48428 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541525  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Y-90 hAFP-31
yttrium Y 90 DOTA monoclonal antibody HuAFP31
Yttrium Y 90 DOTA Monoclonal Antibody HuAFP31
Yttrium Y 90 Tacatuzumab Tetraxetan
Yttrium Y-90 Tacatuzumab Tetraxetan

External Source Codes: 
CAS Registry Number 476413-07-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 425347
PDQ Open Trial Search ID 425347 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541525

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H25N5O7.Y
code C48428
Contributing_Source FDA
Legacy_Concept_Name Yttrium_Y_90_DOTA_Monoclonal_Antibody_HuAFP31
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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