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Version: 16.11d (Release date: 2016-11-28)
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Yttrium Y-90 Tacatuzumab Tetraxetan (Code C48428)

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Terms & Properties

Preferred Name: Yttrium Y-90 Tacatuzumab Tetraxetan

Definition: A radioimmunoconjugate comprised of the humanized monoclonal antibody tacatuzumab, directed against alpha fetoprotein, that is conjugated to the chelating agent tetraxetan and radiolabeled with the beta-emitting radioisotope Yttrium Y 90. Yttrium Y 90 tacatuzumab tetraxetan binds to tumor cells expressing alpha fetoprotein, thereby selectively delivering a cytotoxic dose of beta radiation.

NCI-GLOSS Definition: A substance being studied in the treatment of liver cancer. HuAFP31 is a monoclonal antibody that can bind to tumor cells that make a protein called alpha fetoprotein (AFP). It is linked to a radioactive substance called yttrium Y 90, which may help kill the cancer cells. Yttrium Y 90 DOTA monoclonal antibody HuAFP31 is a type of radioimmunoconjugate.

Label: Yttrium Y-90 Tacatuzumab Tetraxetan

NCI Thesaurus Code: C48428 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541525  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AFP-Cide
Y-90 hAFP-31
YTTRIUM Y-90 TACATUZUMAB TETRAXETAN
Yttrium Y-90 Tacatuzumab Tetraxetan
Yttrium Y 90 DOTA Monoclonal Antibody HuAFP31
yttrium Y 90 DOTA monoclonal antibody HuAFP31
Yttrium Y 90 Tacatuzumab Tetraxetan

External Source Codes: 
CAS Registry Number 476413-07-7 (see NLM ChemIDplus info)
FDA UNII Code GJ2416WK6Y
PDQ Closed Trial Search ID 425347
PDQ Open Trial Search ID 425347 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541525

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C16H25N5O7.Y
code C48428
Contributing_Source FDA
Legacy_Concept_Name Yttrium_Y_90_DOTA_Monoclonal_Antibody_HuAFP31
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48428

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