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Version: 17.06d (Release date: 2017-06-26)
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Larotaxel (Code C48427)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Larotaxel

Definition: A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.

NCI-GLOSS Definition: A substance that is being studied in the treatment of breast cancer. It belongs to the family of drugs called taxane derivatives.

Display Name: Larotaxel

Label: Larotaxel

NCI Thesaurus Code: C48427 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0392979  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Larotaxel
LAROTAXEL
RPR-109881
RPR 109881A
Taxoid-109881
XRP9881

External Source Codes: 
CAS Registry Number 156294-36-9 (see NLM ChemIDplus info)
FDA UNII Code TWQ8K8A81Y
PDQ Closed Trial Search ID 42554
PDQ Open Trial Search ID 42554 (check for NCI PDQ open clinical trial info)
UMLS CUI C0392979

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C45H53NO14
code C48427
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name XRP9881
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48427

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