|Larotaxel (Code C48427)|
|Terms & Properties|
Preferred Name: Larotaxel
Definition: A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.
NCI-GLOSS Definition: A substance that is being studied in the treatment of breast cancer. It belongs to the family of drugs called taxane derivatives.
Display Name: Larotaxel
NCI Metathesaurus Link: C0392979 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||156294-36-9 (see NLM ChemIDplus info)|
|FDA UNII Code||TWQ8K8A81Y|
|PDQ Closed Trial Search ID||42554|
|PDQ Open Trial Search ID||42554 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|