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Version: 17.12d (Release date: 2017-12-26)
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Larotaxel (Code C48427)

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Terms & Properties

Preferred Name: Larotaxel

Definition: A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.

NCI-GLOSS Definition: A substance that is being studied in the treatment of breast cancer. It belongs to the family of drugs called taxane derivatives.

Display Name: Larotaxel

Label: Larotaxel

NCI Thesaurus Code: C48427 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0392979  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
RPR 109881A

External Source Codes: 
CAS Registry Number 156294-36-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42554
PDQ Open Trial Search ID 42554 (check for NCI PDQ open clinical trial info)
UMLS CUI C0392979

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C45H53NO14
code C48427
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name XRP9881
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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