skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.08d (Release date: 2017-08-28)
SearchBox Top
SearchBox Bottom
Volociximab (Code C48426)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Volociximab

Definition: A chimeric monoclonal antibody with potential antineoplastic activity. Volociximab binds to and inhibits the activity of alpha(5)beta(1) integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI05)

NCI-GLOSS Definition: A monoclonal antibody that is being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Volociximab binds to a protein that is found on cells that line some tumor blood vessels. It is a type of angiogenesis inhibitor.

Label: Volociximab

NCI Thesaurus Code: C48426 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541160  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
anti-a5-beta1 Integrin
Anti-alpha5-beta1 Integrin

External Source Codes: 
CAS Registry Number 558480-40-3 (see NLM ChemIDplus info)
FDA UNII Code 496K5Z02NW
PDQ Closed Trial Search ID 415313
PDQ Open Trial Search ID 415313 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541160

Other Properties:
     Name Value (qualifiers indented underneath)
code C48426
Contributing_Source FDA
Legacy_Concept_Name Volociximab
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom