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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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SB-AS15 Adjuvant (Code C48421)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: SB-AS15 Adjuvant

Definition: A vaccine adjuvant containing CpG 7909, monophosphoryl lipid, and QS-21 with potential antineoplastic and immunostimulatory activities. CpG 7909 is a synthetic 24-mer oligonucleotide containing 3 CpG motifs that selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens. Monophosphoryl lipid is a detoxified derivative of lipid A, a component of Salmonella minnesota lipopolysaccharide (LPS); this agent may enhance humoral and cellular responses to various antigens. QS-21 is a purified, naturally occurring saponin derived from the South American tree Quillaja saponaria Molina and exhibits various immunostimulatory activities. Combinations of monophosphoryl lipid and QS-21 may be synergistic in inducing humoral and cellular immune responses. (NCI05)

Display Name: SB-AS15 Adjuvant

Label: SB-AS15 Adjuvant

NCI Thesaurus Code: C48421 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541296  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
SB-AS15 Adjuvant
SB AS15

External Source Codes: 
PDQ Closed Trial Search ID 373865
PDQ Open Trial Search ID 373865 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541296

Other Properties:
     Name Value (qualifiers indented underneath)
code C48421
Contributing_Source CTRP
Legacy_Concept_Name SB-AS15_Adjuvant
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48421

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