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Version: 16.11d (Release date: 2016-11-28)
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Picoplatin (Code C48416)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Picoplatin

Definition: A new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called platinum analogs.

Display Name: Picoplatin

Label: Picoplatin

NCI Thesaurus Code: C48416 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0671135  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMD473
Cis-Amminedichloro (2-Methylpyridine) Platinum (II)
JM473
NX-473
Picoplatin
PICOPLATIN
Platinum, Amminedichloro(2-methylpyridine)-, (SP-4-3)-
ZD0473

External Source Codes: 
CAS Registry Number 181630-15-9 (see NLM ChemIDplus info)
FDA UNII Code B5TAN0L720
PDQ Closed Trial Search ID 441243
PDQ Open Trial Search ID 441243 (check for NCI PDQ open clinical trial info)
UMLS CUI C0671135

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C6H7N.2Cl.Pt.H3N
code C48416
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Picoplatin
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48416

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