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Version: 17.06d (Release date: 2017-06-26)
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Paclitaxel-Loaded Polymeric Micelle (Code C48415)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Paclitaxel-Loaded Polymeric Micelle

Definition: A biodegradable poly(ethylene glycol)-poly(D,L-lactide) copolymer micelle nanoparticle-entrapped formulation of paclitaxel with antineoplastic activity. Paclitaxel promotes microtubule assembly and prevents depolymerization, thus interfering with normal mitosis. The copolymer residue increases the water-solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone.

NCI-GLOSS Definition: A form of the anticancer drug paclitaxel used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi sarcoma. It is also used with another drug to treat non-small cell lung cancer. Paclitaxel is mixed with very tiny particles of a substance that makes it easier to dissolve in water. This allows higher doses of paclitaxel to be given. It is a type of antimitotic agent.

Label: Paclitaxel-Loaded Polymeric Micelle

NCI Thesaurus Code: C48415 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1709446  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cynviloq TM
Genexol PM
IG-001
Paclitaxel-Loaded Polymeric Micelle
paclitaxel-loaded polymeric micelle

External Source Codes: 
PDQ Closed Trial Search ID 434427
PDQ Open Trial Search ID 434427 (check for NCI PDQ open clinical trial info)
UMLS CUI C1709446

Other Properties:
     Name Value (qualifiers indented underneath)
code C48415
Legacy_Concept_Name Paclitaxel-Loaded_Polymeric_Micelle
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48415

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