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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Opioid Growth Factor (Code C48413)

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Terms & Properties

Preferred Name: Opioid Growth Factor

Definition: An endogenous pentapeptide with potential antineoplastic and antiangiogenic activities. Opioid growth factor (OGF) binds to and activates the OGF receptor, present on some tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis. (NCI05)

NCI-GLOSS Definition: A substance that relieves pain and is being studied in the treatment of some types of cancer. Opioid growth factors bind to cells in the body, including tumor cells, which have opioid growth factor receptors on the surface. This may help stop the growth of the tumor cells. It may also prevent the growth of blood vessels that tumors need to grow. An opioid growth factor is a type of biological response modifier and a type of antiangiogenesis agent.

Label: Opioid Growth Factor

NCI Thesaurus Code: C48413 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541553  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
opioid growth factor
Opioid Growth Factor

External Source Codes: 
PDQ Closed Trial Search ID 428488
PDQ Open Trial Search ID 428488 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541553

Other Properties:
     Name Value (qualifiers indented underneath)
code C48413
Legacy_Concept_Name Opioid_Growth_Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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