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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Oncolytic Adenovirus Encoding GM-CSF (Code C48412)

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Terms & Properties

Preferred Name: Oncolytic Adenovirus Encoding GM-CSF

Definition: A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.

Label: Oncolytic Adenovirus Encoding GM-CSF

NCI Thesaurus Code: C48412 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1709316  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oncolytic Adenovirus Encoding GM-CSF

External Source Codes: 
PDQ Closed Trial Search ID 434519
PDQ Open Trial Search ID 434519 (check for NCI PDQ open clinical trial info)
UMLS CUI C1709316

Other Properties:
     Name Value (qualifiers indented underneath)
code C48412
Legacy_Concept_Name Oncolytic_Adenovirus_Encoding_GM-CSF
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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