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Version: 17.06d (Release date: 2017-06-26)
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Veltuzumab (Code C48406)

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Terms & Properties

Preferred Name: Veltuzumab

Definition: A humanized monoclonal antibody directed against the CD20 antigen with potential antineoplastic activity. Following binding, veltuzumab triggers complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) in cells that overexpress CD20. CD20 antigen is a hydrophobic transmembrane protein located on pre-B and mature B lymphocytes.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of lymphoma. It binds to the protein CD20, which is found on B cells (a type of immune system cell) and some types of lymphoma cells. This causes the immune system to kill the cancer cells. IMMU-106 is a type of monoclonal antibody.

Display Name: Veltuzumab

Label: Veltuzumab

NCI Thesaurus Code: C48406 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2746054  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD20 Monoclonal Antibody hA20
hA20
HCD20
IMMU-106
MoAb hA20
Monoclonal Antibody hA20
Veltuzumab
VELTUZUMAB
veltuzumab

External Source Codes: 
CAS Registry Number 728917-18-8 (see NLM ChemIDplus info)
FDA UNII Code BPD4DGQ314
PDQ Closed Trial Search ID 428486
PDQ Open Trial Search ID 428486 (check for NCI PDQ open clinical trial info)
UMLS CUI C2746054

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For non-Hodgkin's lymphoma
code C48406
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_hA20
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48406

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