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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Veltuzumab (Code C48406)

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Terms & Properties

Preferred Name: Veltuzumab

Definition: A humanized monoclonal antibody directed against the CD20 antigen with potential antineoplastic activity. Following binding, veltuzumab triggers complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) in cells that overexpress CD20. CD20 antigen is a hydrophobic transmembrane protein located on pre-B and mature B lymphocytes.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of lymphoma. It binds to the protein CD20, which is found on B cells (a type of immune system cell) and some types of lymphoma cells. This causes the immune system to kill the cancer cells. IMMU-106 is a type of monoclonal antibody.

Display Name: Veltuzumab

Label: Veltuzumab

NCI Thesaurus Code: C48406 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2746054  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD20 Monoclonal Antibody hA20
MoAb hA20
Monoclonal Antibody hA20

External Source Codes: 
CAS Registry Number 728917-18-8 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 428486
PDQ Open Trial Search ID 428486 (check for NCI PDQ open clinical trial info)
UMLS CUI C2746054

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For non-Hodgkin's lymphoma
code C48406
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_hA20
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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