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Version: 17.06d (Release date: 2017-06-26)
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Lucatumumab (Code C48405)

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Terms & Properties

Preferred Name: Lucatumumab

Definition: A fully human monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.

Display Name: Lucatumumab

Label: Lucatumumab

NCI Thesaurus Code: C48405 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2980061  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD40 Monoclonal Antibody CHIR-12.12
CHIR-12.12
HCD-122
Lucatumumab
LUCATUMUMAB
Monoclonal Antibody CHIR-12.12

External Source Codes: 
CAS Registry Number 903512-50-5 (see NLM ChemIDplus info)
FDA UNII Code P0EP9VFC4R
PDQ Closed Trial Search ID 432936
PDQ Open Trial Search ID 432936 (check for NCI PDQ open clinical trial info)
UMLS CUI C2980061

Other Properties:
     Name Value (qualifiers indented underneath)
code C48405
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_CHIR-12_12
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48405

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