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Version: 17.06d (Release date: 2017-06-26)
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Lucatumumab (Code C48405)

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Terms & Properties

Preferred Name: Lucatumumab

Definition: A fully human monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.

Display Name: Lucatumumab

Label: Lucatumumab

NCI Thesaurus Code: C48405 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2980061  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD40 Monoclonal Antibody CHIR-12.12
Monoclonal Antibody CHIR-12.12

External Source Codes: 
CAS Registry Number 903512-50-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 432936
PDQ Open Trial Search ID 432936 (check for NCI PDQ open clinical trial info)
UMLS CUI C2980061

Other Properties:
     Name Value (qualifiers indented underneath)
code C48405
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_CHIR-12_12
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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