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Version: 17.06d (Release date: 2017-06-26)
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Tandutinib (Code C48404)

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Terms & Properties

Preferred Name: Tandutinib

Definition: A piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. It may stop cancer cell growth by blocking certain enzymes. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Tandutinib

Label: Tandutinib

NCI Thesaurus Code: C48404 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1143028  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Piperazinecarboxamide, 4-(6-Methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-
CT53518
MLN518
MLN 518
Tandutinib
TANDUTINIB
tandutinib

External Source Codes: 
CAS Registry Number 387867-13-2 (see NLM ChemIDplus info)
FDA UNII Code E1IO3ICJ9A
NSC Code 726292 (see NCI DTP info)
PDQ Closed Trial Search ID 353146
PDQ Open Trial Search ID 353146 (check for NCI PDQ open clinical trial info)
UMLS CUI C1143028

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C31H42N6O4
code C48404
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name MLN518
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48404

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