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Version: 17.08d (Release date: 2017-08-28)
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Methylnaltrexone (Code C48403)

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Terms & Properties

Preferred Name: Methylnaltrexone

Definition: A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids.

NCI-GLOSS Definition: The active ingredient in a drug used to relieve certain side effects caused by treatment with opiods (pain killers similar to morphine), such as constipation (hard, dry stools), itching, and low urine flow. Methylnaltrexone binds to opioid receptors outside the brain and may block the side effects of opioid drugs without affecting their ability to relieve pain. Methylnaltrexone is a type of peripheral opioid receptor antagonist.

Display Name: Methylnaltrexone

Label: Methylnaltrexone

NCI Thesaurus Code: C48403 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0066411  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Quaternary Ammonium Naltrexone

External Source Codes: 
CAS Registry Number 83387-25-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 437863
PDQ Open Trial Search ID 437863 (check for NCI PDQ open clinical trial info)
UMLS CUI C0066411

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H26NO4
code C48403
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Methylnaltrexone
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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