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Version: 17.06d (Release date: 2017-06-26)
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Lestaurtinib (Code C48402)

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Terms & Properties

Preferred Name: Lestaurtinib

Definition: An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)

NCI-GLOSS Definition: A drug being studied in the treatment of acute leukemias and some other types of cancer. It binds to a protein that is present on the surface of some types of cancer cells and stops them from dividing. CEP-701 is a type of receptor tyrosine kinase inhibitor and a type of indolocarbazole alkaloid.

Display Name: Lestaurtinib

Label: Lestaurtinib

NCI Thesaurus Code: C48402 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541677  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-
CEP-701
KT-5555
Lestaurtinib
LESTAURTINIB
lestaurtinib
SPM-924

External Source Codes: 
CAS Registry Number 111358-88-4 (see NLM ChemIDplus info)
FDA UNII Code DO989GC5D1
PDQ Closed Trial Search ID 367053
PDQ Open Trial Search ID 367053 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541677

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H21N3O4
code C48402
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Lestaurtinib
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48402

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