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Version: 17.06d (Release date: 2017-06-26)
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Retaspimycin Hydrochloride (Code C48401)

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Terms & Properties

Preferred Name: Retaspimycin Hydrochloride

Definition: The hydrochloride salt of a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of HSP90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis.

Display Name: Retaspimycin Hydrochloride

Label: Retaspimycin Hydrochloride

NCI Thesaurus Code: C48401 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1708447  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride
Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)-, monohydrochloride
Retaspimycin Hydrochloride

External Source Codes: 
CAS Registry Number 857402-63-2 (see NLM ChemIDplus info)
FDA UNII Code 928Q33Q049
PDQ Closed Trial Search ID 437784
PDQ Open Trial Search ID 437784 (check for NCI PDQ open clinical trial info)
UMLS CUI C1708447

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C31H45N3O8.HCl
code C48401
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name IPI-504
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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