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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 131 Monoclonal Antibody 8H9 (Code C48400)

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Terms & Properties

Preferred Name: Iodine I 131 Monoclonal Antibody 8H9

Definition: A radioimmunoconjugate consisting of the iodine 131-radiolabeled murine IgG1 monoclonal antibody 8H9 directed against the surface immunomodulatory glycoprotein 4Ig-B7-H3 with potential radioimaging and radioimmunotherapeutic uses. Iodine I 131 monoclonal antibody 8H9 binds to 4Ig-B7-H3 (human B7-H3 with 4 Ig-like domains) and may be used to radioimage and/or destroy tumor cells that express tenascin. 4Ig-B7-H3 inhibits T-cell activation and the production of effector cytokines such as interferon-gamma and interleukin-4; it is expressed on the cell membranes of a wide variety of tumors of neuroectodermal, mesenchymal and epithelial origin and is highly expressed on monocyte-derived dendritic cells (mdDCs). In vitro, it has been shown that monoclonal antibody-mediated masking of 4Ig-B7-H3 on neuroblastoma cells resulted in the enhancement of natural killer (NK)-mediated lysis of target cells.

Display Name: Iodine I 131 Monoclonal Antibody 8H9

Label: Iodine I 131 Monoclonal Antibody 8H9

NCI Thesaurus Code: C48400 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541591  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Iodine I 131 MOAB 8H9
Iodine I 131 Monoclonal Antibody 8H9

External Source Codes: 
PDQ Closed Trial Search ID 380753
PDQ Open Trial Search ID 380753 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541591

Other Properties:
     Name Value (qualifiers indented underneath)
code C48400
Contributing_Source CTRP
Legacy_Concept_Name Iodine_I_131_Monoclonal_Antibody_8H9
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48400

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