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Version: 17.06d (Release date: 2017-06-26)
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Ingenol Mebutate (Code C48398)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ingenol Mebutate

Definition: A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol mebutate activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis.

Label: Ingenol Mebutate

NCI Thesaurus Code: C48398 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1452152  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Butenoic acid, 2-methyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a- octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a- methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester, (2Z)-
I3A
Ingenol-3-angelate
Ingenol Mebutate
INGENOL MEBUTATE
PEP-005
PEP005

External Source Codes: 
CAS Registry Number 75567-37-2 (see NLM ChemIDplus info)
FDA UNII Code 7686S50JAH
PubMedID Primary Reference 19178487 (see PubMed Primary Reference info)
UMLS CUI C1452152

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C25H34O6
code C48398
Contributing_Source FDA
Legacy_Concept_Name Ingenol_3-Angelate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48398

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