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Version: 17.06d (Release date: 2017-06-26)
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Iloprost (Code C48397)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Iloprost

Definition: A prostacyclin analogue with potential chemopreventive activity. Iloprost binds to the prostacyclin receptor in various target cells, thereby causing vasodilation, inhibition of platelet aggregation, and decreased tumor cell adhesion to endothelium among other effects. Prostacyclin is a naturally occurring eicosanoid with anti-inflammatory, antineoplastic, and anti-metastatic properties. (NCI05)

NCI-GLOSS Definition: A substance that is being studied in the prevention of lung cancer. It belongs to the family of drugs called prostaglandin analogs.

Label: Iloprost

NCI Thesaurus Code: C48397 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0079594  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric Acid
Ciloprost
Iloprost
ILOPROST
iloprost
Iloprost Clathrate
Pentanoic Acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-
Ventavis
ZK 36374

External Source Codes: 
CAS Registry Number 78919-13-8 (see NLM ChemIDplus info)
FDA UNII Code JED5K35YGL
ChEBI ID CHEBI:63916 (see ChEBI info)
PDQ Closed Trial Search ID 365679
PDQ Open Trial Search ID 365679 (check for NCI PDQ open clinical trial info)
UMLS CUI C0079594

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H32O4
code C48397
Contributing_Source FDA
Legacy_Concept_Name Iloprost
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48397

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