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Version: 17.06d (Release date: 2017-06-26)
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HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine (Code C48392)

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Terms & Properties

Preferred Name: HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine

Definition: A vaccine comprised of HER-2-neu and carcinoembryonic antigen synthetic (CEA) peptides, combined with the adjuvants granulocyte-macrophage colony stimulating factor (GM-CSF), and Montanide ISA-51 with potential antineoplastic activity. HER-2-neu, CEA peptides, GM-CSF, Montanide ISA-51 vaccine may stimulate a cytotoxic T-cell response against HER-2-neu- and CEA-expressing tumor cells. The GM-CSF adjuvant stimulates the proliferation of monocytes and monocyte differentiation into macrophages and dendritic cells, immunohematopoietic elements with important antitumoral functions. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens.

Label: HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine

NCI Thesaurus Code: C48392 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1708269  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HER-2-neu, CEA Peptides, GM-CSF, Montanide ISA-51 Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 442901
PDQ Open Trial Search ID 442901 (check for NCI PDQ open clinical trial info)
UMLS CUI C1708269

Other Properties:
     Name Value (qualifiers indented underneath)
code C48392
Legacy_Concept_Name HER-2-neu_CEA_Peptides_GM-CSF_Montanide_ISA-51_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48392

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