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Version: 17.06d (Release date: 2017-06-26)
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Everolimus (Code C48387)

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Terms & Properties

Preferred Name: Everolimus

Definition: A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)

NCI-GLOSS Definition: A drug used to treat advanced kidney cancer that did not respond to treatment with certain other anticancer drugs. It is also being studied in the treatment of other types of cancer. Afinitor stops cancer cells from dividing and may block the growth of new blood vessels that tumors need to grow. It also decreases the body's immune responses. It is a type of immunosuppressant and a type of antiangiogenesis agent.

Display Name: Everolimus

Label: Everolimus

NCI Thesaurus Code: C48387 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0541315  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
42-O-(2-Hydroxy)ethyl Rapamycin
RAD 001

External Source Codes: 
CAS Registry Number 159351-69-6 (see NLM ChemIDplus info)
NSC Code 733504 (see NCI DTP info)
PDQ Closed Trial Search ID 372905
PDQ Open Trial Search ID 372905 (check for NCI PDQ open clinical trial info)
UMLS CUI C0541315

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For with unresectable, locally advanced or metastatic neuroendocrine tumors of pancreatic origin
Chemical_Formula C53H83NO14
code C48387
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Everolimus
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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