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Version: 16.10e (Release date: 2016-10-31)
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Eculizumab (Code C48386)

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Terms & Properties

Preferred Name: Eculizumab

Definition: A humanized monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. (NCI05)

NCI-GLOSS Definition: A monoclonal antibody used to prevent red blood cells from being destroyed in patients with paroxysmal nocturnal hemoglobinuria (PNH), a red blood cell disorder. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body. Eculizumab blocks a protein in the blood that causes the breakdown of red blood cells.

Label: Eculizumab

NCI Thesaurus Code: C48386 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541483  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alexion
ECULIZUMAB
Eculizumab
eculizumab
h5G1.1
Immunoglobulin, Anti-(Human Complement C5 Alpha-Chain) (Human-Mouse Monoclonal 5G1.1 Heavy Chain), Disulfide with Human-Mouse Monoclonal 5G.1.1 Light Chain, Dimer
Monoclonal antibody 5G1.1
Soliris

External Source Codes: 
CAS Registry Number 219685-50-4 (see NLM ChemIDplus info)
FDA UNII Code A3ULP0F556
PDQ Closed Trial Search ID 415541
PDQ Open Trial Search ID 415541 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541483

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Paroxysmal Nocturnal Hemoglobinuria
code C48386
Contributing_Source FDA
Legacy_Concept_Name Eculizumab
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48386

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