skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Degarelix (Code C48385)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Degarelix

Definition: A long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes.

NCI-GLOSS Definition: A drug that is used to treat advanced prostate cancer and is also being studied in the treatment of benign prostatic hyperplasia. Degarelix binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland. This causes the body to stop making testosterone, which prostate cancer needs to grow. Degarelix is a type of GnRH antagonist.

Display Name: Degarelix

Label: Degarelix

NCI Thesaurus Code: C48385 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0971731  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Degarelix
DEGARELIX
degarelix
FE200486
Firmagon
N-acetyl-3-(naphtalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-4-((((4S)-2,6-dioxohexahydropyrimidin-4-yl)carbonyl)amino)-L-phenylalanyl-4-(carbamoylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamide

External Source Codes: 
CAS Registry Number 214766-78-6 (see NLM ChemIDplus info)
FDA UNII Code SX0XJI3A11
PDQ Closed Trial Search ID 441235
PDQ Open Trial Search ID 441235 (check for NCI PDQ open clinical trial info)
UMLS CUI C0971731

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For advanced prostate cancer
Chemical_Formula C82H103ClN18O16
code C48385
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Degarelix
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C48385

Mainbox Bottom