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Version: 17.08d (Release date: 2017-08-28)
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Bardoxolone (Code C48382)

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Terms & Properties

Preferred Name: Bardoxolone

Definition: A synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. CDDO may block enzymes involved in inflammation and cancer growth. It is a type of antineoplastic plant product.

Label: Bardoxolone

NCI Thesaurus Code: C48382 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0762434  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid
2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid
Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-
RTA 401

External Source Codes: 
CAS Registry Number 218600-44-3 (see NLM ChemIDplus info)
FDA UNII Code 7HT68L8941
NSC Code 711193 (see NCI DTP info)
PDQ Closed Trial Search ID 453589
PDQ Open Trial Search ID 453589 (check for NCI PDQ open clinical trial info)
UMLS CUI C0762434

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Antineoplastic and anti-inflammatory
Chemical_Formula C31H41NO4
code C48382
Contributing_Source FDA
Legacy_Concept_Name CDDO
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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